Disable the Debug Core

If you want to remove a debug core from your project:
  1. Open the Project Editor.
  2. Click the Debugger tab.
  3. Turn off the Debugger Auto Instantiation option.
  4. Click OK.
  5. Re-compile the design.

The software removes the debug profile from your design, but does not remove it from disk. So you can re-enable the debug profile again by turning on the Debugger Auto Instantiation, specifying the profile name, and recompiling.